Patient: On November 28, 2008, I found an unintentional swelling on the outside of my left breast without pain. On December 11, she underwent surgery and was discharged on January 1, 2009 after undergoing “excision of left breast mass + modified radical surgery of left breast cancer”. Will endocrine therapy alone work? Do I need chemotherapy? Ma Shudong, Department of Oncology, Southern Hospital of Southern Medical University: After reading your relevant medical records and pathological data, you have undergone radical surgery for left-sided breast cancer. If it is determined that the tumor size is 1×1cm, pathology: infiltrating ductal carcinoma, axillary lymph nodes (0/4), ER (++), PR (+), Her-2:IHC (++), FISH (-), but lack of specific pathological descriptions such as tissue grading and the presence of choroidal carcinoma emboli, it is suggested that: (1) if there is no metastasis from other sites (through relevant examinations) (1) If there is no metastasis from other sites (by relevant examination), endocrine adjuvant therapy, i.e. oral triamcinolone acetonide, should be administered. (2) Some experts believe that it is better to add adjuvant chemotherapy when the tissue or nuclear grade is high, and even chest wall radiotherapy in the case of choroidal carcinoma embolism, because modified radical surgery has been performed, the effect of adding or not adding adjuvant chemotherapy is similar on whether recurrence or metastasis occurs later. (The above reply is based on the accuracy of the pathological data in the medical records, especially based on the results of Her-2 FISH (-)) Patient: Thank you very much, Professor Ma, I still have some questions: my family later took the slide to the pathological consultation at Zhongshan First Hospital, and the results of the original Shunde People’s Hospital were different, ER (+), PR (-), Her-2 ( (+); is this result that endocrine treatment is not effective, can I come to your hospital directly to see you for treatment? When will the consultation be held? I am currently taking an endocrine medication (Toremifene citrate tablets). Yesterday, I sent 5 more white tablets to the Cancer Hospital for ER, PR and Her-2 tests, and I guess I will have the results at the end of the week. The results will be available by the end of the week. I’m waiting for the test results from the cancer hospital. Patient: The results from the oncology hospital have come out, ER (++++), PR (-), Her-2 (-), the doctor at the oncology hospital said that endocrine therapy is possible, as for chemotherapy, it can be done or not, now I decided to do chemotherapy, Professor Ma, which chemotherapy regimen do you think is best for me? Thank you very much for helping me in my busy schedule with online consultation. Ma Shudong, Department of Oncology, Southern Hospital of Southern Medical University: If you decide to have chemotherapy, it should be given before endocrine therapy. Chemotherapy regimens are 6 cycles of CAF (CEF) or CMF, 4-6 cycles of AC or EC, and it is fine for you to choose either one of them.