Lymphoma is divided into stages I, II, III and IV. Stage IV is the last stage, which is definitely advanced. In addition to the lymphoma cells in the lymph nodes, there will be metastases in several organs outside the lymph nodes. Although the stage is finished, some patients with sensitive lymphoma will completely lose their lymphoma cells through chemotherapy. If the lymphoma partially shrinks after chemotherapy, other regimens should be considered for chemotherapy. Of course, autologous hematopoietic stem cell transplantation can also be considered, and patients with suitable clinical trials can also choose to participate in clinical trials. If only local lymph nodes remain after chemotherapy, local radiotherapy can also be performed.