Omeprazole can be taken with cephalosporin, as prescribed by your doctor. Cephalosporins belong to a kind of antibiotics, mainly used to treat infections caused by sensitive bacteria. Omeprazole is a drug that inhibits the secretion of gastric acid, from the drug metabolism, most of the cephalosporin and omeprazole, there is no obvious drug interaction, so cephalosporin and omeprazole can be used together, but they have some precautions respectively. 1. Cephalosporin, if there is a history of penicillin allergy, is not recommended to use cephalosporin. 2. Omeprazole, although and most of the cephalosporin, there is no drug metabolism interaction, but omeprazole and other drugs, there are interactions, such as cardiovascular commonly used antiplatelet drugs, such as clopidogrel, as well as antifungal drugs, etc., and omeprazole is an interaction. Consult your pharmacist or doctor when using.