Acute pancreatitis shock is common in patients with severe pancreatitis, the main reasons for shock are the following three points: First, the effective blood volume is insufficient, because in the occurrence of acute pancreatitis, there will be pancreatic peripheral and abdominal inflammation, so that a large number of plasma components of the extravasation of blood caused by the reduction of effective blood volume, and in addition to the occurrence of severe vomiting or diarrhea will cause dehydration, but also caused by the effective blood volume is insufficient. Secondly, bradykinin-like substances lead to peripheral vasodilatation, acute pancreatitis, once the activation of various digestive enzymes, which plays a major role in the activation of enzymes such as phospholipase A2, kinin releasing enzyme and pancreatic vasopressor, etc., which kinin releasing enzyme can be made to change the kininogen into bradykinin and pancreatic kallikrein, which will make the vasodilatation and increased permeability caused by oedema, shock. Thirdly, acute pancreatitis complicates gastrointestinal bleeding, such as upper gastrointestinal bleeding mainly due to stress ulcers or gastric mucosal erosion bleeding, lower gastrointestinal bleeding is mainly due to pancreatic necrosis penetrating the transverse colon. So acute pancreatitis is a more serious disease, it is recommended to be diagnosed early, and to actively cooperate with the treatment.