Clinically, most multiple sclerosis is not able to get the new crown vaccine, only a small number of long-term stable patients are considered to be able to get it. Multiple sclerosis is the most common central nervous system (CNS) immune-mediated inflammatory demyelinating disease, if the disease is active or is taking oral immunosuppressive drugs, this time to go to the new crown vaccine, the new crown vaccine will be less effective, in addition to the possibility of exacerbating the original disease. If some of the patients have been completely recovered after systematic treatment and continue to be stable, this kind of patients can try to get the new crown vaccine. It is recommended that patients with multiple sclerosis be vaccinated with the new vaccine at a vaccination center under the supervision of a specialist.