Forehead wrinkle injection after a little depression, may be related to edema caused by local unevenness, extrusion and treatment effect is not good and other factors, the main treatment is to pay attention to observation, pay attention to strengthen the care and again injected wrinkle injection and so on. 1. Pay attention to observation. Within one week after the injection of wrinkle removing needle, the local area may have slight edema, for the different degree of swelling, so the local area may appear unevenness, this situation is generally based on observation, after the edema subsides, the local unevenness will gradually disappear. 2. Pay attention to strengthen skin care. After the wrinkle treatment, avoid rubbing and squeezing the local area, so as not to aggravate the local deformation. 3. Re-inject the wrinkle removing injection. For the wrinkle treatment that does not achieve the expected purpose, the injection treatment can be carried out again after a certain interval of time, generally the interval time is about 3~6 months. Due to the different personal constitution and different technical operation skill of the treating doctor, it will affect the treatment effect, so we must choose regular medical institutions to carry out standardized treatment.