Interstitial changes in both lungs do not heal on their own. There are many causes of bipulmonary interstitial changes, including hypersensitivity pneumonitis, connective tissue-associated interstitial pneumonitis, drug-induced interstitial pneumonitis, and idiopathic interstitial pneumonitis. Interstitial changes in both lungs are due to multiple causes of interstitial and alveolar inflammatory changes, with interstitial changes and pulmonary fibrosis predominating, leading to loss of alveolar-capillary function and affecting the function of lung gas exchange. It appears as diffuse foci of membranous glassy exudates with increased and disorganized lung texture on chest X-ray or CT. The prognosis of bilateral interstitial lung changes varies depending on the etiology, but they are usually irreversible, require medication, and do not resolve spontaneously. If interstitial lung changes are detected, early medical attention is recommended.