The normal value of hepatitis B virus DNA quantification is usually less than 10^3 or 1000 copies/ml. However, it should be noted that hepatitis B virus DNA quantification within the normal range just means that the virus is low, slow or does not replicate at this time. However, because the hepatitis B virus still exists in the body, it may also be infectious. When the quantification of hepatitis B virus DNA of patients with triple positive is more than 10^5 or the value of liver transaminase is more than twice of the normal value, timely antiviral treatment can be considered, and commonly used drugs include interferon and nucleotide analogs. Through reasonable treatment, hepatitis B e antigen can become negative, and very few patients may also have hepatitis B surface antigen become negative. However, due to hepatitis B has the characteristics of hepatophilicity, pansophilicity, variability and cccDNA. Even if the viral quantification is normal, there may be recurrence, so it is very necessary to review the quantification of hepatitis B virus DNA and liver function regularly.