There are many diseases that can cause coughing and weakness, as follows: 1. Infection by pathogenic microorganisms, such as bacteria, viruses, and atypical pathogenic bacteria, mostly accompanied by fever, and patients will have symptoms of weakness. 2. Patients with pulmonary tuberculosis can also have symptoms of weakness, as well as symptoms of tuberculosis toxicity such as low fever, night sweats, and wasting, and also respiratory symptoms such as coughing, sputum, chest pain, and coughing up blood. Patients with lung tumor can also have symptoms of malaise and coughing, accompanied by clinical manifestations such as fever, chest pain, dyspnea, and wasting, etc. The diagnosis can be made clearly through lung CT, bronchoscopy, and lung puncture biopsy. Target cell drug therapy, etc.