Men with penile pain may be due to urethral lesions or penile cavernous lesions, it is recommended to go to the hospital for examination to clarify the cause and then treat it symptomatically. First, if there is inflammation of the urethra and pain, it is recommended to take levofloxacin hydrochloride capsules orally 1 capsule/time, 3 times/day, or cefixime capsules 1 capsule/time, 2 times/day, and observe whether there is relief of pain symptoms for a week. Secondly, if there are pain caused by urethral stones and tumors, it is recommended to conduct urethroscopic examination to clarify the specific location and nature of the lesion, and then perform urethroscopic stone fragmentation and stone extraction, or urethroscopic tumor removal, and the pain can be relieved after removing the relevant lesion. Thirdly, if there is local painful sensation caused by penile cavernous sclerosis, anti-infection treatment can be used in the early stage, such as oral cefixime capsule 1 capsule/time, 2 times/day for one week. In the later stage, local painful nodules can appear, and local sclerodactyly excision treatment needs to be considered to remove the relevant diseased tissues, and the pain can gradually return to the normal state.