Pain is the most common symptom of cancer patients and a major cause of their quality of life. 1986, the World Health Organization (WHO) issued the “Principles of Three-step Pain Management for Cancer”, which recommended the implementation of a three-step pain management program for cancer worldwide. According to the three-step treatment principle, nearly 80% of patients can have basic pain relief, but 20% of patients cannot solve their pain problems due to ineffective oral administration or high side effects of oral opioids, which seriously affects their quality of life. For patients with poor drug effects, the pain department can provide pain relief through precise neurointerventional techniques, including: 1. Drug neurodesis (abdominal plexus block): ethanol block therapy of the abdominal plexus is used for pain caused by upper abdominal tumors, especially pancreatic cancer pain, and about 60-85% of patients can obtain pain-free. The procedure is within the scope of minimally invasive surgery, and a special puncture needle is applied to precisely locate and puncture into place under X-ray fluoroscopy, and anhydrous alcohol is injected for the block to obtain the best results. The effect of ethanol is good and long lasting. In elderly, debilitated & advanced patients, the results of nerve-destroying drugs are better than surgical procedures. Pain relief lasts up to 5 weeks to 4 months. 2. Central target-controlled analgesia technique: Central target-controlled analgesia, also known as programmable drug infusion pump technique, is one of the most advanced methods in the international pain community in recent years for the treatment of cancer pain and chronic intractable pain such as central pain and postherpetic neuralgia. This method can directly apply drugs to the spinal cord and brain, and the dose of applied drugs is only 1/300 of the dose needed for oral administration, avoiding the toxic side effects brought by large amount of oral medication, and can write corresponding programs for targeted drug delivery and personalized services for different conditions and pain patterns of patients, which can achieve satisfactory analgesic effects. Its biggest advantage is safety, small trauma, remarkable efficacy, simple operation, good patient tolerance and few complications, and it is suitable for all patients with cancer pain and chronic intractable pain who are ineffective by other traditional treatment methods and medication, or cannot tolerate the side effects of medication, with high success rate. 3.Spinal cord electrical stimulation therapy: The neuralgia caused by radiation therapy is opioid non-responsive pain, at this time, the nerve modulation technique is very important. The spinal cord stimulation electrodes are implanted in the corresponding spinal cord stages, and the spinal cord stimulation is carried out by sending electrical stimulation waves through the connected stimulator to achieve neuromodulation and pain relief. 4.Neural destructive therapy: Bone metastasis of cancer is a common cause of bone pain. Bone metastatic cancer pain syndrome is a temporary aggregation of various pain symptoms and signs with certain characteristics during the disease development of cancer patients. This syndrome is mainly due to the compression of bone pathways and nerve tissues. Since bone pain is opioid semi-responsive pain, it requires neurodestructive treatment. Depending on the condition, physical or chemical nerve destruction treatment can be chosen. 5.Epidural pain relief: Epidural pain relief technique is a method of injecting pain medication into the epidural cavity to block spinal nerve conduction and produce segmental analgesia. Epidural cavity block can block both the somatic and autonomic nerves, and the blocking range is larger and the effect is exact. Because the epidural cavity block technique is simple to operate, with little damage and exact effect, it is widely used in clinical practice. The mechanism of cancer pain is very complicated and has many causes. The degree of pain will increase as the disease changes, so it is important to seek timely medical consultation at the early stage of cancer pain and receive professional and systematic standardized treatment for pain relief. The same attention should be paid to cancer pain during the whole process of cancer treatment. Through correct assessment, diagnosis and treatment of cancer pain at different stages by pain doctors to achieve the best efficacy, it is also to lay a good foundation for cancer treatment.