Chronic eczema on the hands of hard skin need to actively treat chronic eczema, commonly used treatments include general treatment (such as looking for sensitizers, etc.), topical medications (such as glucocorticoids, etc.), oral medications (such as antihistamines, etc.), physical therapy and so on. 1. General treatment: search for and avoid contact with irritants and sensitizers, and avoid scratching the affected area to avoid secondary infection. 2. Local medication: glucocorticosteroids are the main medication for chronic eczema, commonly used medications include mometasone furoate, dexamethasone, halometasone, etc. Glucocorticosteroids not only stop itching and anti-inflammatory, but also reduce the symptoms of lesions, but should not be applied for a long time. 3. Oral medication: If the lesions are more extensive, it is recommended that oral antihistamines, such as loratadine, cetirizine, etc., to alleviate the symptoms, and if the secondary infection, you can use sensitive antibiotics, such as cephalosporin, amoxicillin, etc., based on the use of anti-allergic drugs. 4. Physical therapy: hospitals choose ultraviolet irradiation to supplement the treatment. All of the above drugs need to be used under the guidance of a doctor to avoid blind use of medication, it is recommended that patients go to the hospital in a timely manner, in accordance with the doctor’s instructions for the use of medication.