Patients with high anti-mutant citrullinated wave protein antibody should further clarify the cause of the high antibody and undergo medication and surgical treatment to address the cause of the disease. High anti-mutant citrullinated wave protein antibody is mainly seen in rheumatoid arthritis. Anti-mutant citrullinated waveform protein antibody, i.e., anti-MCV antibody, has high specificity for the diagnosis of rheumatoid arthritis, and has high specificity and sensitivity in the diagnosis of rheumatoid arthritis, and it can also reflect the disease activity of rheumatoid arthritis patients. Patients with high anti-mutant citrullinated wave protein antibody need to cooperate with their physicians to improve the diagnosis of antikeratin antibody, anti-cyclic citrullinated peptide antibody, rheumatoid factor, blood sedimentation, CRP, X-ray and other relevant auxiliary examinations. Patients diagnosed with rheumatoid arthritis can be treated with anti-rheumatic drugs, such as methotrexate, leflunomide, etc., and non-steroidal anti-inflammatory drugs, such as loprofen sodium, etc., and, if necessary, surgical treatments, such as synovectomy and knee replacement, are needed. All of the above medications should be used in accordance with medical advice. It is recommended that patients with high anti-mutant citrullinated wave protein antibodies should go to the rheumatology and immunology departments of regular hospitals for detailed consultation and standardized treatment as prescribed.