Muscle biopsy is generally seen in localized muscle masses, and may be considered when the nature of the mass is unclear. Biopsy is mainly divided into two major costs, one is the cost of sampling, usually need to consider anesthesia for sampling, the cost of about 3000-5000 yuan. The other is the pathology of the specimen, and sometimes further immunohistochemistry is required, which costs about$2,000. So the cost of a muscle biopsy is about 4000-5000 RMB. Muscle biopsy can determine the nature of the localized lesion. If the lesion is benign, generally speaking, it can be followed up for observation or excision treatment. If the lesion is malignant, surgical resection or even amputation should be considered. According to the nature, scope and size of the localized lesion, active treatment will help to recover as soon as possible.