Venlafaxine Hydrochloride may cause difficulty in urination, but difficulty in urination is not necessarily caused by Venlafaxine Hydrochloride, and urinary disorders need to be ruled out. Venlafaxine Hydrochloride is an antidepressant drug that inhibits the reuptake of 5-hydroxytryptamine and norepinephrine. Taking venlafaxine Hydrochloride may cause some damage to kidney function, causing patients to experience difficulty urinating. Allergic patients are forbidden to use venlafaxine hydrochloride, taking this drug can cause insomnia, headache, diarrhea, nausea, loss of appetite, tinnitus and other adverse reactions. It is important to note that difficulty in urination may not be caused by taking venlafaxine hydrochloride, as urinary disorders such as kidney stones, ureteral stones, cystitis, prostate enlargement, and other urinary disorders can also produce symptoms of difficulty in urination. Taking venlafaxine hydrochloride after the symptoms of dysuria, should promptly go to the hospital to improve the examination, clear the cause of the disease and then give targeted treatment.