Adapalene gel has some exfoliating and anti-keratinizing effects and can cause slight flaking of the skin when applied to normal skin. If this occurs, topical application of zinc oxide boric acid ointment or vitamin E ointment can be used to provide an anti-allergy and reduce skin irritation. This ointment is mainly used for closed-jaw acne, such as white acne or blackhead acne rash, folliculitis papules and acne manifestations on the face and chest and back, and the appearance of such rashes can be enhanced with oral isotretinoin soft capsules or vitamin E capsules.