Blood pressure has been taking medication can not be lowered, should actively find the cause of the disease, exclude secondary hypertension, under the guidance of specialists to adjust antihypertensive drugs, and at the same time to improve the bad habits of life. 1. Secondary hypertension: if secondary hypertension, primary diseases should be searched for, such as screening for renal organic disease and pheochromocytoma. Renal organic hypertension should strictly limit sodium intake; renal vascular hypertension should choose interventional surgery or surgical treatment according to the condition; pheochromocytoma should choose surgical resection and so on. Only by actively treating the primary disease, the blood pressure can be lowered. 2. Drug factors: the selection of antihypertensive drugs is not suitable, such as nifedipine tablets and other short-acting preparations, such drugs have a fast onset of action, the role of instability, taking irregularly, blood pressure is often poorly controlled; in addition, the selection of the drug dose is not enough, not a combination of medication, etc., will also lead to blood pressure can not be lowered. At this time, you can use long-acting preparations, such as amlodipine, nifedipine extended-release tablets, etc.; can also be combined with several other drugs, such as hydrochlorothiazide, Irbesartan, and so on. 3. Bad Lifestyle: To strictly adopt a low-salt and low-fat diet, exercise, relax the mind and regular work and rest, etc. Improving life habits can help reduce blood pressure. Therefore, patients with high blood pressure who have been unable to lower their blood pressure after taking medication should seek medical attention as soon as possible.