Adenocarcinoma in situ with microinfiltration means that the adenocarcinoma in situ further deteriorates and develops.
The basement membrane of adenocarcinoma in situ is intact and the cancer tissues are confined to the epithelial layer, while the microinvasive cancer cells have penetrated the basement membrane and there is extra-epithelial infiltration. Adenocarcinoma in situ is almost invasive and metastatic, and the probability of invasive metastasis of microinvasive cancer is significantly higher than that of adenocarcinoma in situ.
Patients with adenocarcinoma in situ after radical resection do not need to take anti-tumor measures such as adjuvant radiotherapy and chemotherapy, and patients have long survival time and good prognosis.
However, in a few cases, micro-infiltrated cancer cells may have already entered the blood circulation and metastasized to other organs of the body, which cannot be detected by pathological examination, and then several courses of chemotherapy or radiotherapy should be carried out after surgical resection, which can basically remove the residual cancer cells in the body.
In conclusion, even if carcinoma in situ is accompanied by micro-infiltration, most of the patients can be cured after active treatment.