The causes of hepatomegaly caused by chronic granulocytic leukemia include drug injury, malignant leukocyte infiltration, and hepatic vascular obstruction. 1. Drug damage: patients with chronic granulocytic leukemia can suffer a certain degree of liver damage due to the prolonged use of chemotherapeutic drugs such as cyclophosphamide and hypertriglycerides. Damage to the liver can cause liver function abnormalities, thus causing hepatomegaly. 2. Malignant leukocyte infiltration: due to leukocyte infiltration, the liver is damaged, thus causing symptoms of hepatomegaly. 3. Obstruction of hepatic blood vessels: If the lymph nodes are enlarged, the blood vessels around the liver are pressurized, resulting in obstruction of blood return, thus causing hepatomegaly. An enlarged spleen will also affect the pressure on the hepatic veins, causing obstruction of blood flow and resulting in hepatosplenomegaly. In order to alleviate the above symptoms, early correction and regular treatment under medical supervision are recommended to avoid adverse complications.