Itchy small blisters on the cracks of the toes may be tinea pedis, eczema, and need to be treated specifically according to the cause. If it is tinea pedis, you can use antifungal drugs to treat it; if it is eczema, you can use glycerine lotion, zinc oxide ointment and other drugs to treat it. 1. Tinea pedis: blistering tinea pedis caused by fungal infection can lead to symptoms of itchy small blisters on the toe seams. You can use topical terbinafine ointment clotrimazole ointment and other antifungal medication, with oral itraconazole capsules, fluconazole capsules and other antifungal medications if the disease is long. 2. Eczema: internal and external stimulation of a variety of factors causing inflammatory skin reactions, resulting in skin eczema, the acute stage may also cause skin erythema, blisters, itching and other symptoms, can also lead to the toe seam long small blisters are very itchy, can be used externally with glycerine lotion, zinc oxide ointment, boric acid solution and other drugs, but also with Chlorotetracycline, cetirizine, and other antihistamine drugs. Toe seam long small blisters very itchy, there may be other reasons, it is recommended to go to the hospital in a timely manner to clarify the cause of the disease, and follow the doctor’s instructions for treatment, do not self-medication.