Chronic cholecystitis rarely causes elevated total bilirubin, and non-acute episodes usually have no obvious manifestations or laboratory abnormalities. Elevated total bilirubin can be seen in a variety of jaundice disorders. Chronic cholecystitis is a chronic inflammatory lesion of the gallbladder, most often combined with gallbladder stones. In the non-acute phase, chronic cholecystitis patients mainly manifest chronic right upper abdominal discomfort, abdominal distension or hidden pain, etc., the symptoms are not obvious, and the blood routine, liver function and other laboratory tests are not obvious abnormalities, and the total bilirubin is rarely elevated. When the inflammation is acute, signs of infection such as abdominal pain, chills, fever, elevated blood leukocytes, etc. are present, and elevated total bilirubin is not common. Total bilirubin is an important indicator of liver function, and elevated levels can be seen in jaundice caused by a variety of reasons, such as hemolytic jaundice, obstructive jaundice, hepatocellular jaundice, etc. The cause of jaundice can also be identified based on the level of elevated total bilirubin, but chronic cholecystitis can rarely cause total bilirubin to be elevated. It is recommended to go to the hospital as soon as possible to find out the cause of the elevated total bilirubin, and then follow the doctor’s instructions to standardize the treatment.