Perforation of the eardrum, or tympanic membrane perforation, does not necessarily require medication, and the principle of treatment is different for different types. If the perforation is caused by otitis media, the main focus is to control the infection; if the perforation is caused by traumatic injury, it can be healed by itself; if the perforation is large or does not heal for a long time, surgery can be considered to repair it. 1. Perforation of the tympanic membrane in otitis media (1) Acute otitis media perforation of the tympanic membrane: generally oral cephalosporin, penicillin antibiotic treatment, such as: cefdinir, amoxicillin and so on. Local can also be drops with ofloxacin ear drops, inflammation is controlled, perforation of the eardrum generally about two weeks will heal on its own. (2) Chronic purulent otitis media perforation of the eardrum: antibiotics should be used first for anti-inflammatory, such as penicillin or cephalosporin, followed by early tympanic membrane repair surgery. 2. Traumatic tympanic membrane perforation (1) Treatment as soon as possible: professional doctors should be approached as soon as possible for appropriate treatment, and appropriate treatment should be taken according to the specific condition. (2) Postoperative precautions: After treatment, keep the ear canal clean and dry, and do not let water in. Avoid swimming and other activities that may allow water to enter the ear canal until the perforation has healed. 3. Large perforation or long term non-healing: If the perforation is large or fails to heal on its own over a long period of time, patch treatment or surgical repair may be considered. If you have a perforated eardrum, you should choose the right treatment for your specific condition under the guidance of a professional doctor, and if you need to use medication, you should choose it under the guidance of a specialist.