Large closed pimples, usually nodular or cystic acne, can be reasonably removed by medication, surgery, and phototherapy. 1.Drugs: (1) Chemical exfoliation: such as common fruit acid, salicylic acid, etc., applying them to the local skin can play a role in reducing the accumulation of keratin and prompting sebum can be excreted smoothly. (2) Benzoyl peroxide: such as the commonly used benzoyl peroxide lotion, etc., has a relatively strong bactericidal ability, can play a role in killing Propionibacterium acnes, in addition to reducing the secretion of sebaceous glands. (3) Retinoic acid drugs: such as commonly used isotretinoin, retinoic acid cream, etc., these drugs can play a role in inhibiting cellular keratinization and proliferation, as well as reducing sebaceous cell secretion. 2. Surgical treatment: closed mouth acne patients with pustules and other symptoms, can consider the use of surgical incision for drainage, can effectively lift the inflammation, to prevent the emergence of secondary infection. 3. Photoelectric treatment: such as red and blue light treatment, through red and blue light irradiation of local skin lesions, thereby relieving inflammation, inhibiting the growth of Propionibacterium acnes, to achieve the therapeutic purpose. Once you have a big closed mouth acne, you should pay attention to the hospital in time, under the guidance of the doctor to carry out reasonable treatment.