Renal failure creatinine 400μmol / L has entered the chronic kidney disease stage 4, mainly for the treatment of complications, commonly used to correct acidosis, water electrolyte metabolic disorders of drugs such as (sodium bicarbonate, etc.), antihypertensive drugs (nifedipine, etc.), detoxification drugs (urotoxicity Qing, etc.), renal osteomalacia drugs (osteopontanol, etc.). Some patients have reached stage 5 of renal disease and need active dialysis treatment. 1. Correct acidosis, water, electrolyte metabolism disorder drugs: oral sodium bicarbonate tablets for mild cases, and intravenous infusion of sodium bicarbonate injection for severe cases. For electrolyte disorders such as hyperkalemia, drugs such as calcium polystyrene sulfonate can be applied to promote potassium excretion from feces. 2. Antihypertensive drugs: Generally, the blood pressure of patients with chronic renal failure should be controlled below 130/80mmHg, and calcium channel blockers such as nifedipine extended-release tablets can be used. 3. Detoxification drugs: urethane particles for chronic renal failure caused by azotemia, uremia, etc., can effectively reduce urea nitrogen, urinary creatinine to stabilize renal function. 4. Renal bone disease drugs: for patients with low calcium, oral osteotriol can be taken, but during the treatment, pay attention to review the blood phosphorus, blood calcium and parathyroid hormone measurement. It is recommended that patients with chronic renal failure go to the hospital in a timely manner, under the guidance of the physician to choose the treatment medication, do not self-medication, so as not to delay the condition.