Thigh fever with burning sensation may be due to infection, herpes zoster, dermatomyositis, contact dermatitis and so on. 1. Infection: when the patient’s thigh fever with burning sensation, it may be caused by infection. Usually when the leg is infected with viral, bacterial and especially fungal infections, it will produce dandruff lymphadenitis as well as cellulitis locally, and the thighs will be feverish with redness, swelling, pain, dysfunction and other symptoms. 2. Herpes zoster: the disease is mainly caused by varicella zoster virus caused by acute infectious skin diseases, the patient will appear thigh fever with burning sensation, mainly manifested as a band-like distribution of clusters of painful blisters. 3. Dermatomyositis: fever with burning sensation in thighs may be caused by dermatomyositis, which is usually an autoimmune disease that includes skin and muscle, and is mainly affected by infections, heredity and other factors. 4. Contact dermatitis: when the skin comes into contact with exogenous substances, it can lead to an inflammatory reaction in the skin at or beyond the contact site, causing fever with burning sensation in the thighs, accompanied by mild edema, erythema and other symptoms. Thigh fever may be caused by other reasons, it is recommended to go to the hospital in a timely manner, under the diagnosis of the doctor, according to the patient’s specific condition performance, targeted treatment.