2-year-old baby runny nose cough in the middle of the night, considering the possibility of acute upper respiratory tract infection, but also does not rule out other diseases, such as allergic rhinitis with allergic cough, pneumonia and so on. 1. Acute upper respiratory tract infection: the common cause of runny nose and cough at the same time because of acute upper respiratory tract infection, including the common cold, viral pharyngitis and other diseases, which is the most common common common cold. 2. Allergic rhinitis with allergic cough: allergic rhinitis and allergic cough at the same time, can also show symptoms of a runny nose and cough, at the same time with these two allergic diseases should be suspected of allergic body. 3. Pneumonia: Although pneumonia is a lower respiratory tract infection, it can also cause a runny nose and cough. 2-year-old baby runny nose cough in the middle of the night, there may be other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.