Breast cancer ulcers can be treated with fluorouracil ointment, mupirocin ointment and other topical medicines under doctor’s instruction. Breast cancer ulcers are mainly caused by tumor invasion into the skin or skin damage after radiotherapy. 1. Tumor invasion of skin: Breast cancer tumor invasion of skin leads to skin ulcers, which can be treated with isacridine lactate solution and erythromycin ointment under doctor’s guidance to promote wound healing. The drugs have anti-inflammatory and antibacterial effects and are mainly used to treat small burns and ulcer surface infections. 2. Skin injury after radiotherapy: after radiotherapy for breast cancer, skin ulceration may occur, generally can use fusidic acid cream, mupirocin ointment and other drugs for treatment under the guidance of doctors, such drugs have antibacterial effect and are mainly used for skin infection, and are forbidden for patients who are allergic to mupirocin. At the same time, for breast cancer skin ulcers can also use some growth factor ointment such as recombinant human epidermal growth factor gel, in order to promote skin healing. It is recommended that patients go to the hospital for treatment in a timely manner, do not self-medicate to avoid danger, and pay attention to wearing loose clothes to avoid friction in daily life.