The hard cuticles on both sides of the nails may be caused by keratosis pilaris, periungual warts, etc. Generally, the treatment is directed at the cause of the disease, often using medication, physical therapy methods, such as urea ointment, liquid nitrogen freezing and so on. 1. Keratosis pilaris: long-term friction or extrusion stimulation on both sides of the nails may lead to keratosis pilaris, you can use hot water to soak your hands, and then apply hand cream to improve the symptoms, but also local topical keratolytic agents, such as urea ointment, retinoic acid cream and so on. 2. periungual warts: periungual warts are caused by human papillomavirus infection, manifested in both sides of the nails or nail beds, under the nails appeared hard pimples, often fused into a piece of rough surface, sometimes visible black spots. It can be removed by local topical salicylic acid cream, imiquimod cream, etc. It can also be removed by physical therapy, such as liquid nitrogen cryotherapy and laser therapy. All of the above medications should be used under the guidance of a professional doctor, avoid self-medication. Hard corns on both sides of the nails may also have other causes (such as true white nails), it is recommended to go to the hospital in time to improve the examination, to clarify the cause of the disease and then give targeted treatment.