The best way to treat kidney disease needs to start with the cause of the disease that leads to kidney disease. In the case of primary nephropathy, a pathologic puncture biopsy of the kidney is needed, and most pathologic types require treatment with adequate amounts of glucocorticoids, in combination with immunosuppressive agents. In some cases, a combination of renin-angiotensin-aldosterone receptor antagonists, such as ambrisentan, irbesartan, valsartan, and captopril, is also needed. If the nephropathy is caused by secondary diseases, such as diabetic nephropathy, hypertensive nephropathy, gouty nephropathy and so on. It is necessary to actively control the primary disease, strictly use oral hypoglycemic drugs combined with insulin to control blood glucose up to the standard, use calcium channel blockers and RAAS blockers to control blood pressure completely up to the standard, can be combined with the appropriate use of tretinoin and other drugs to inhibit immune response. At the same time, strictly control the intake of salt, calories and foods with high purine content, and regularly do the corresponding review to adjust the treatment program.