Diabetic macroangiopathy mainly involves the aorta, coronary arteries, cerebral arteries, renal arteries, and peripheral arteries of the limbs. Its main manifestation is atherosclerotic lesions, leading to coronary heart disease, ischemic or hemorrhagic cerebrovascular disease, renal arteriosclerosis, and limb arteriosclerosis. Peripheral atherosclerosis is often dominated by arterial lesions of the lower extremities, manifested by pain, abnormal sensation and intermittent rupture of the lower extremities, and severe inadequate blood supply may lead to gangrene of the extremities. Diabetic macroangiopathy occurs early and has a high incidence, and is the most important cause of death in type 2 diabetes. More than 75% of all diabetic deaths are due to macroangiopathy, of which 75% are due to coronary artery disease and 25% to cerebrovascular disease. Coronary heart disease is four times more common among diabetics than among non-diabetics. 70% of diabetics have macrovascular complications. The cost of treating cardiovascular and atherosclerotic diseases accounts for about 80% of the cost of various diabetes-related treatments. It is no longer infections and ketoacidosis that threaten the lives of diabetic patients, but mainly complications and comorbidities of the cardiovascular system.