Nucleic acid negative antigen positive is defined as a negative nucleic acid test and a positive antigen for neococcal pneumonia, which may indicate a healed infection, appropriate vaccinations, false positives, and other conditions. 1. Cured after infection: when patients with negative antigen positive nucleic acid are infected by the corresponding virus, the body’s immune response will produce the corresponding antibodies to destroy the virus, and nucleic acid is mainly used to detect whether there is a virus and other pathogens, so when the infection is cured, the virus disappears and the antibody survives in the body for a long time, then there will be a case of negative antigen positive nucleic acid. 2. Vaccination of the corresponding vaccine: because the vaccine is mainly through the pathogenic microorganisms, after a specific method of making the immune preparation. When the human body has been vaccinated, it will stimulate the body’s immune system to produce the appropriate antibodies, which can eliminate the virus. Since the vaccine contains antigenic substances of the virus, a negative nucleic acid test and a positive antigen test may occur. 3. False Positive: As the self cell apoptosis will also expose the antigen, so when the detection of poor environmental conditions, improper operation of the detector or the patient’s own factors, resulting in detection errors may occur in the case of nucleic acid negative antigen positive. Nucleic acid-negative antigen-positive patients are recommended to go to the hospital in time for relevant examinations to clarify the cause of the disease, and then carry out systematic treatment under the guidance of the doctor. Tip: In this article, “new coronary pneumonia, new coronary virus pneumonia” has been renamed to “new coronary virus infection” on December 26, 2022, as announced by the National Health Commission.