Headache on both sides of the head can be seen in neurological headache, upper respiratory tract infection, cerebrovascular disease, etc., need to choose the appropriate drugs according to the cause of the disease. 1. Commonly used drugs for neurological headache are antidepressants (such as doxepin), benzodiazepines (such as diazepam, lorazepam), etc., which can relieve headache, insomnia and other symptoms. 2. Headaches caused by upper respiratory tract infections are mainly treated symptomatically, and commonly used drugs are non-steroidal anti-inflammatory drugs, such as aspirin and acetaminophen. 3. If the headache is caused by cerebral blood supply insufficiency, cerebral arteriosclerosis and other cerebrovascular diseases, painkillers such as ibuprofen can be used to relieve the symptoms of pain. At the same time, it is necessary to actively treat the original disease. For example, antiplatelet drugs (such as aspirin) are commonly used for cerebral blood supply insufficiency, lipid-lowering drugs (such as simvastatin), and drugs to improve cerebral circulation (such as betahistine) are commonly used for cerebral arteriosclerosis. However, it is important to note that the drugs must be used under the guidance of a doctor and not blindly abused.