In August 2010, the American Diabetes Association (ADA) and the American Cancer Society (ACS) officially published the Consensus Report on Diabetes and Cancer, which showed that numerous epidemiological studies confirmed that primary type 2 diabetes can increase the risk of several common cancers (liver, pancreatic, endometrial, colorectal, breast, and bladder cancers ), but decrease the risk of prostate cancer. Diabetes and cancer share certain risk factors, and there are many questions to explore. Mechanisms of Diabetes Prone to Tumor Combination Recent studies have found a significant increase in the incidence of malignant tumors in diabetic patients compared to non-diabetic patients, and the mechanisms by which diabetes is prone to tumor combination are not yet clear. The mechanism of diabetes mellitus susceptible to tumor is not yet clear. ★ Hyperglycemia Glucose is the direct and only source of energy for tumor cells, and hyperglycemia can cause oxidative damage to genetic material, etc. ★ Hyperinsulinemia The heterogeneity and complexity of diabetic different organ tissues exposed to hyperinsulinemia make it difficult to quantitatively assess the risk of insulin promoting cancer in different organs in different individuals. ★ The role of various growth factors (e.g. IGF-1, VEGF, TGF, etc.) and immune factors, etc. ★Advanced glycosylation end products (AGEs), etc.? AGEs were found to promote the growth of human colon cancer cells SW-480 cells in a concentration-dependent manner.CyclinD1 plays a key role in the transition of cells from G1 phase to S phase, and AGEs promote CyclinD1 expression. While telomerase plays an important role in malignant tumorigenesis and progression, AGEs increased telomerase activity in SW-480 cells and promoted cell proliferation.