H. pylori quadruple therapy is a combination of 2 antibiotics, 1 bismuth agent, and 1 proton pump inhibitor taken orally with different dosages of each drug as prescribed by the doctor. 1.2 Antibiotics: The combination of 2 antibiotics is usually amoxicillin 1.0 g + metronidazole 400 mg twice daily or tetracycline 500 mg + metronidazole 400 mg etc. taken twice daily. Helicobacter pylori is a bacterium that is treated with 2 antibiotics to control the infection and the medication needs to be taken with a meal. 2.1 Bismuth: 1 bismuth agent, such as bismuth potassium citrate capsule, 0.6g each time in the morning and evening, with the effect of protecting the gastric mucosa, usually taken half an hour before meals, twice a day. 3.1 Proton pump inhibitor: 1 proton pump inhibitor mainly with omeprazole, each time to take 20 mg morning and evening, which has the effect of inhibiting gastric acid secretion, usually half an hour before meals. Patients with Helicobacter pylori infection in the body need to be actively examined and cooperate with the doctor for treatment, if not actively treated, it may lead to delayed disease, thus inducing gastritis, gastric ulcer, gastric cancer and other diseases. The drug should be taken under the guidance of a doctor.