Foreign bodies entering the vasculature in the vast majority of cases cannot be eliminated, but will run through the vasculature and be deposited in the distant lung or kidney tissue, sometimes in the capillaries, where they are usually deposited forever and cause an inflammatory reaction, as PM2.5 does to humans, but this foreign body is very specific, being composed of inorganic salts or soluble components that may dissolve in the blood and be excreted with the breath or kidneys. However, in the vast majority of cases, it is more harmful if it is a scattered particle, and if it is a separate piece of foreign body it may cause cerebral embolism, or embolism of the arteries of the lower and upper limbs, causing insufficient blood supply, or even necrosis of the distant limb, requiring amputation.