Moderate chronic inflammation of gastric sinus mucosa with intestinal chemosis is a precancerous lesion, which should be treated with standardized treatment of the primary pathology and regular review of gastroscopy. The treatment of moderate chronic inflammation of gastric sinus mucosa with enterocolitis includes removing the cause of the disease, relieving the symptoms and improving the inflammatory reaction of gastric mucosa. For example, individualized adjustment of diet and lifestyle, symptomatic acid suppression, gastric mucosa protection, gastrointestinal dynamics and digestive therapy, such as omeprazole, bismuth potassium citrate, domperidone, digestive enzyme tablets and so on. Chronic gastritis with H. pylori infection should be treated with HP radical therapy, such as omeprazole, amoxicillin, clarithromycin, bismuth potassium citrate. Chronic atrophic gastritis with moderate or severe intestinal epithelial hyperplasia has the risk of cancer, and should be followed up regularly, with repeat gastroscopy in 3-6 months and pathological biopsy of the lesions, to dynamically observe the changes of the disease, and if there is any progression, it can be treated accordingly. Moderate chronic inflammation of gastric sinus mucosa with intestinal epithelial hyperplasia should be standardized under doctor’s guidance, and if there is any discomfort, go to the hospital in time to avoid delaying the condition.