Cephalosporin and levofloxacin can be used together. Commonly used antibiotics are clinically classified into ten categories, cephalosporin belongs to the beta lactam class of antibiotics, including one generation of cephalosporin, two generations of cephalosporin, three generations of cephalosporin and four generations of cephalosporin, each generation of cephalosporin targeting different pathogenic bacteria, the bactericidal effect also varies. Levoxyl belongs to quinolone antibiotics, also divided into first, second, third and fourth generation, and levofloxacin, belongs to the third generation of quinolone antibiotics, the two drugs are used together without contraindications. For patients with severe infections, in order to increase the anti-infective effect, reduce the occurrence of drug resistance, and not to miss the time of treatment, the combination of drugs is recommended. However, it should be understood that cephalosporin is a time-dependent antibiotic that requires multiple doses to maintain a certain blood concentration, while levofloxacin is a concentration-dependent antibiotic that requires a full dose to achieve therapeutic effect.