Muscle aches and pains after suffering from lupus erythematosus need to be assessed firstly for the activity of the disease, and the use of hormones and immunosuppressants (methylprednisolone, hydroxychloroquine, etc.) should be adjusted according to changes in the disease, while non-steroidal anti-inflammatory drugs (aspirin, celecoxib, etc.) may be used for symptomatic treatment with attention paid to the day-to-day management and regimen. 1. Assessment of condition: Lupus requires long-term medication and management as it cannot be cured. When the patient develops uncomfortable symptoms, he/she should be alerted to the presence of disease activity. Patients should consult the Rheumatology and Immunology Department in a timely manner, and the specialist should determine whether there is any change in the condition, and further adjust the medication according to the degree of disease activity, such as the adjustment of hormones and immunosuppressants (methylprednisolone, hydroxychloroquine, etc.). 2. Symptomatic treatment: non-steroidal anti-inflammatory drugs can be chosen, commonly used drugs include aspirin, celecoxib, etc., which can be used to treat muscle and joint symptoms caused by lupus erythematosus, as well as systemic symptoms such as fever, and the common adverse reactions are gastrointestinal irritation, such as nausea, stomach pain, acid reflux, bloating, diarrhea, etc., and it is prohibited to use it in people who are allergic to the drugs. 3. General treatment: strengthen skin management, avoid direct sunlight, do not wear chemical fiber clothes, reduce the friction on the skin, pay attention to warmth, live and eat regularly, avoid exertion, ensure a good sleep, and carry out some functional exercises under the guidance of the doctor to enhance the body’s resistance. Muscle aches and pains after suffering from lupus erythematosus are recommended to go to the hospital for examination in time. All medicines should be used under the guidance of professional doctors and avoid self-medication.