Long-term failure to ovulate can be treated with medication, if there is an underlying disease, it is recommended that the underlying disease can be treated first. Non-ovulation is a disorder of ovulation, the clinical use of drugs including clomiphene, letrozole and other drug treatment. However, the medication is required to be used in accordance with the course of treatment, and at the same time need to follow the doctor’s instructions, do not blindly use their own medication. For patients with obesity, emaciation, poor lifestyle habits and underlying diseases such as hyperthyroidism, hypothyroidism and pituitary tumors, it is necessary to first change the original lifestyle and correct the underlying diseases, and then carry out ovulation induction therapy. If there is any discomfort during the treatment period, it is recommended to consult a doctor in time for symptomatic treatment.