If stones grow in the bile ducts after gallbladder removal, observation can be the mainstay if there are no obvious symptoms, but surgery is needed when symptoms recur. Bile duct stones include intrahepatic bile duct stones and extrahepatic bile duct stones. When they do not cause obvious symptoms, they can be observed first. When stones cause obstruction of the hepatic bile ducts, they can lead to bile duct infections due to poor drainage of the bile ducts, which can lead to acute cholangitis. When bile duct infection occurs, antibiotics against gram-negative bacilli, such as piperacillin, cefoperazone, gentamicin and so on, can be used for anti-infection treatment. After the infection is controlled, timely surgical treatment is needed, such as endoscopic retrograde cholangiopancreatic lithotripsy or choledochotomy and T-tube drainage. Specific treatment programs vary according to the condition, it is recommended to consult a doctor in a timely manner, and follow the doctor’s instructions for medication and treatment.