The third dose of New Crown vaccine can be given 6 months after completion of New Crown inactivated vaccination; the third dose of recombinant subunit vaccine should be given 4 weeks after completion of the second dose. After the completion of inactivated new crown vaccine, with the passage of time, the antibody level in the body of the vaccinee gradually decreases, so it is necessary to receive the third booster shot to improve the antibody level. According to China’s regulations, the third booster shot for people over 18 years old should be administered six months after the completion of the second inactivated New Crown vaccine. The third dose of the recombinant subunit vaccine should be administered 4 weeks after the completion of the second vaccination and within 6 months after the completion of the first vaccination. According to available studies, one month after completion of the third dose of the new crown inactivated vaccine, antibody levels were elevated about 5-fold compared to one month after completion of the second dose. The rapid increase in antibody levels to a higher level is able to cope with the current mutation of the NeoCrown virus, obtaining better protection and reducing the risk of serious illness.