Indobufen and clopidogrel are both antiplatelet drugs, but they have different mechanisms of action, different adapted to the population, different side effects and different contraindications. 1. Different mechanisms of action: Indobufen plays an anti-platelet coagulation role through reversible and selective inhibition of platelet receptors. Even if bleeding occurs, it is easier to control and safer. Clopidogrel is irreversible inhibition of platelet receptors, thus inhibiting the role of platelet aggregation. This drug needs to be metabolized into active substances in the body so that it can exert its medicinal effects. 2. Different adaptive groups: indobufen is suitable for venous thrombosis, ischemic cerebrovascular lesions, ischemic cardiovascular lesions caused by atherosclerosis. It can also be used to prevent thrombosis during hemodialysis. Clopidogrel is indicated for patients with acute coronary syndrome, patients with recent ischemic stroke (from 7 days to less than 6 months), and patients with recent myocardial infarction (from a few days to less than 35 days). 3. Side effects are different: indobufen, a drug with relatively minor side effects, commonly constipation, abdominal pain, dyspepsia, nausea, headache, skin allergic reactions. Clopidogrel has more side effects, there may be subcutaneous bleeding, bleeding gums, gastrointestinal bleeding and so on. Gastrointestinal reaction is obvious. 4. Different contraindications: Indobufen is contraindicated in patients with congenital or acquired bleeding disorders, pregnant and lactating women. Clopidogrel is contraindicated in patients with severe liver damage, peptic ulcer, intracranial hemorrhage. The specific use of which drug, it is recommended that it is best to use the drug under the guidance of the local doctor.