A solid intrahepatic space is defined as the presence of a substantial space-occupying lesion in the liver, but the nature of the lesion needs to be further investigated. A solid intrahepatic space is an imaging finding that describes the formation of a solid nodule, mass, or other tissue in the liver that replaces the normal liver tissue. The nature of the occupancy is generally categorized as benign or malignant and needs to be determined by pathologic examination. Common benign occupations include hepatic adenoma and hepatic hemangioma. Common malignant occupations are primary hepatocellular carcinoma and secondary hepatocellular carcinoma. For substantial intrahepatic occupations, it is necessary to determine their benign or malignant nature at an early stage, and then actively follow the doctor’s advice for the next step of treatment.