H. pylori that fails to kill the first time treatment is usually cured after a pause. Failure to kill H. pylori the first time of treatment may be related to the patient’s failure to take the medication on time, omission of medication, and the development of bacterial resistance. Therefore, the second eradication treatment should be replaced with other antibiotics, and if possible, a drug sensitivity test can be performed first in order to select a sensitive antibiotic. In addition, patients need to follow the doctor’s instructions to take the drugs during the treatment, do not arbitrarily stop taking the drugs, intermittent medication, or arbitrarily increase or decrease the dosage of the drugs, so as not to affect the therapeutic effect. It is recommended that patients undergo a carbon 13 or carbon 14 breath test one month after stopping the medication to understand the clearance of H. pylori. If the patient is diagnosed with H. pylori infection, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor to carry out targeted treatment, in order to reduce the adverse effects of the disease.