13 Trisomy is high risk and not necessarily flippable. Because high risk represents a higher chance of occurrence, it is not always possible to flip it. The main features of trisomy 13 are severe mental retardation, peculiar facial features such as microcephaly and craniosynostosis, malformations of the hands, feet and genitals, and often lethal malformations such as congenital heart disease and renal malformations. If only the non-invasive DNA test currently shows a high risk of trisomy 13, further testing by amniocentesis is needed to confirm the diagnosis, as high risk does not necessarily mean there is a problem. If further testing by amniocentesis makes it clear that the fetus has three chromosome 13s, the diagnosis of a child with trisomy 13 can be confirmed. In this case, the pregnancy can be terminated under medical supervision.