Unilateral zygomatic bone protrusion may be caused by congenital heredity and cannot be pressed down by sleeping, if it has no effect on the appearance, no treatment is needed, if it has effect on the appearance, surgical treatment is needed. Single zygomatic bone protrusion is mostly considered to be caused by congenital heredity, which is a normal physiological phenomenon and cannot be pressed down by sleeping. If zygomatic bone protrusion has no effect on the appearance, generally do not need to take measures to treat. If zygomatic bone protrusion affects the appearance, surgical treatment is needed, such as osteotomy, zygomatic bone endoprosthesis and so on. If a patient experiences mild zygomatic bone protrusion, this can be treated with facial fat grafting to improve the manifestation of facial zygomatic bone protrusion. Generally simple zygomatic bone protrusion can not be improved by sleeping, if the patient’s zygomatic bone protrusion has no effect on the external image, it can not be treated. If the herniated cheekbones have a greater impact on the appearance, it is necessary to consult a doctor in time, and the doctor will choose the appropriate measures to treat the patient according to his/her situation. In addition, for patients who need to undergo surgery, patients should avoid taking anti-inflammatory drugs before surgery.