Once in a while, not sleeping for 48 hours does not usually lead to sudden death, but regularly this may lead to sudden death. Not sleeping for 48 hours may lead to excessive brain fatigue, dizziness, headache, decreased concentration and other symptoms, once in a while, generally will not lead to sudden death. Regularly staying up for 48 hours without sleep may lead to the occurrence of many diseases, such as high blood pressure, diabetes, and myocardial infarction, etc., and is likely to lead to sudden death. Long-term staying up late may cause the body’s immunity to decline, endocrine disorders, aggravate the burden on the heart, the harm is great. It is recommended to develop a good routine, avoid staying up late, and at the same time, you can carry out appropriate exercise and scientific diet.