Four Wonderful Pills and colchicine can be taken together as prescribed by the doctor, and it is recommended to take them at certain intervals. Four Wonderful Pills is a proprietary Chinese medicine, colchicine is a western medicine, there is no clear contraindication in the pairing of Chinese medicine, can be taken together, but it is recommended that the two drugs are taken at an interval of 1-2 hours or more. Si Miao Pill has the effect of clearing heat and inducing dampness (removing heat and dampness in the body), and is mainly used for treating paralysis caused by dampness-heat injection (dampness and heat invading the intestines, bladder, pubic area, lower limbs, etc.), and the specific symptoms can be seen in the symptomatic redness and swelling of the feet and knees, and pain in the tendons and bones. Adverse effects and contraindications of Si Miao Pill are not clear, pregnant women should be cautious to take the drug. Colchicine is used to treat acute attacks of gouty arthritis, but also to prevent acute attacks of recurrent gouty arthritis. The drug’s adverse reactions gastrointestinal symptoms, muscle, peripheral neuropathy, bone marrow suppression and many other manifestations, is prohibited for those who have hypoproliferative hypoplasia of the bone marrow and renal and hepatic insufficiency. Four wonderful pills and colchicine can be used together within the scope of their respective indications, but must be used under the guidance of a physician, and strictly adhere to the medical prescription of medication, in order to avoid the emergence of inter-drug effects.