There is no inevitable connection between gallbladder removal and colon cancer, that is, gallbladder removal will not lead to the occurrence of colon cancer. Current research shows that the etiology of colon cancer is mainly related to the following four factors: 1, genetic: about 20% of colorectal cancer patients, genetic factors may play a very important role. 2, dietary factors: currently, it is believed that high animal protein, high fat and low fiber diet are the factors of high incidence of colorectal cancer. 3, other non-cancerous diseases of colon: such as chronic ulcerative colitis, polyposis, adenoma, etc., which may develop into colorectal cancer. These diseases may develop into colorectal cancer.4. Other: environmental factors, dietary habits, lifestyle, etc. Lack of physical activity and sedentary occupations may have a higher incidence of colorectal cancer than high-intensity physical workers, and overweight and obesity are also considered to be risk factors for colon cancer. Gallbladder removal is not the cause of colon cancer, so gallbladder removal will not lead to colon cancer.