Lung adenocarcinoma is a common pathological type of lung cancer, and its advanced stage patients have more symptoms, the key depends on where it metastasizes to, and the symptoms appear in different locations are different. For patients with advanced lung cancer, many of them can metastasize to the skull and experience discomfort such as headache and dizziness, nausea and vomiting, etc. Patients with pleural effusion can experience shortness of breath, chest tightness and panic; larger tumors cause obstructive pneumonia and symptoms such as coughing and coughing, shortness of breath are more normal; hypoproteinemia and swelling can occur; superior vena cava syndrome can be complicated, with shortness of breath, breath-holding and jugular vein Patients with bone metastases may experience bone pain and other discomfort. There are many conditions in advanced stage patients, the key is where the lung cancer metastasizes to and what complications appear. In the treatment of advanced stage patients, symptomatic treatment is the main focus, so as to minimize patients’ pain, improve patients’ quality of life and prolong their lives as much as possible. No matter what symptoms appear, the treatment should focus on actively treating patients’ symptoms and not increasing patients’ pain.